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What is the principle of gas chromatography ?

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Question added by Ajaz Pathan , Sr QC Supervisor , Astrachem
Date Posted: 2015/01/31
Virendra Vikhare
by Virendra Vikhare , chemist , Rezilabs for Industrial Services / SAECO

Gas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition.

suleyman shaik
by suleyman shaik , Assisstant Manager (Manufacturing) , Dr.Reddy's Laboratories

The sample solution injected into the instrument enters a gas stream which transports the sample into a separation tube known as the "column." (Helium or nitrogen is used as the so-called carrier gas.) The various components are separated inside the column. The detector measures the quantity of the components that exit the column. To measure a sample with an unknown concentration, a standard sample with known concentration is injected into the instrument. The standard sample peak retention time (appearance time) and area are compared to the test sample to calculate the concentration. 

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