“People who don't take risks generally make about two big mistakes a year. People who do take risks generally make about two big mistakes a year.” Do you agree?

Generally to make a mistake is a human tendency which further gives a learning and experience to get the right direction and taking risk is a secondary factor which again may lead to false decision  sometimes but if on the right track may lead to quick success.

yes.“People who don't take risks generally make about two big mistakes a year. People who do take risks generally make about two big mistakes a year.”